PGT-SR Chromosomal Rearrangements Screening in Chennai

Some fertility challenges may be caused by structural changes in chromosomes that are not detected through routine fertility tests. PGT-SR (Preimplantation Genetic Testing for Structural Rearrangements) helps identify embryos with a balanced chromosomal structure before embryo transfer during an IVF cycle.

At Agam Fertility and Women Centre, we combine advanced genetic testing with personalized fertility care to support informed treatment decisions. Our specialists recommend PGT-SR based on your genetic profile, fertility history, and individual reproductive needs.

What is PGT-SR?

PGT-SR is a specialized genetic test performed during IVF for couples in whom one or both partners have a known structural chromosomal rearrangement. By analyzing a few cells from each embryo in a specialized genetics laboratory, PGT-SR helps identify embryos with a balanced chromosomal structure, supporting informed embryo selection and personalized fertility treatment.

Understanding Chromosomal Rearrangements

Chromosomal Structure

Understanding Structural Chromosomal Rearrangements

Chromosomes carry the genetic information that guides growth and development. In some individuals, chromosomes may undergo structural changes. Because these changes may not cause symptoms in the parent, they are often discovered only after fertility investigations, recurrent miscarriages, or genetic testing.

Balanced Translocations

Robertsonian Translocations

Chromosomal Inversions

Other Structural Chromosomal Rearrangements

Purpose

Why is PGT-SR Performed?

PGT-SR is recommended when there is a confirmed structural chromosomal rearrangement that may affect embryo development. Rather than correcting chromosomal changes, PGT-SR provides valuable genetic information that supports clinical decision-making during IVF.

Evaluate embryos for chromosomal balance

Support informed embryo selection

Reduce likelihood of transferring embryos with unbalanced rearrangements

Better understand recurrent loss or repeated IVF failure related to chromosome factors

Personalize fertility treatment based on genetic findings

Candidacy

Who May Benefit from PGT-SR?

PGT-SR may be recommended for individuals or couples who have been diagnosed with a structural chromosomal rearrangement. A detailed fertility evaluation and genetic assessment help determine whether this specialized testing is appropriate.

Have a balanced chromosomal translocation

Have a Robertsonian translocation

Have a chromosomal inversion

Have experienced recurrent miscarriages linked to chromosomal factors

Have had repeated unsuccessful IVF cycles associated with structural abnormalities

Have received abnormal chromosomal results during genetic testing

Have been referred for genetic counselling before IVF

Recommendations

When is PGT-SR Recommended?

PGT-SR may be considered in situations where chromosomal rearrangements have been identified or strongly suspected. Every treatment recommendation is based on a comprehensive fertility assessment and individualized care plan.

Balanced Chromosomal Rearrangements

When one partner carries a balanced structural chromosome change identified through genetic testing.

Recurrent Pregnancy Loss

When repeated miscarriages may be associated with chromosomal imbalance in embryos.

Previous IVF Failure

When chromosomal rearrangements are suspected to contribute to unsuccessful embryo implantation.

Genetic Counselling

When a genetic specialist recommends embryo testing based on chromosomal findings.

Process

How Does PGT-SR Work?

PGT-SR is performed as part of an IVF cycle and follows a carefully coordinated laboratory process.

1

Genetic Evaluation

Your fertility specialist reviews your reproductive history, previous fertility treatments, and chromosomal test results. Genetic counselling helps determine whether PGT-SR is appropriate.

2

IVF Treatment

Eggs are retrieved and fertilized in the embryology laboratory to create embryos.

3

Embryo Biopsy

Once the embryos reach the blastocyst stage, a few cells are gently collected from the outer layer of each embryo for genetic analysis.

4

Genetic Testing

The collected cells are examined to determine whether the embryos have balanced or unbalanced structural chromosome arrangements.

5

Embryo Cryopreservation

Embryos are safely preserved while the genetic analysis is completed.

6

Embryo Transfer

Based on the genetic findings and your fertility evaluation, your fertility specialist recommends the most appropriate embryo for transfer.

Every stage is carried out with precision to support safe laboratory practices and informed treatment planning.

Advantages

Benefits of PGT-SR

For suitable patients, PGT-SR provides valuable genetic insights during IVF treatment. The role of PGT-SR depends on your individual medical history and genetic findings, making specialist evaluation essential.

Supports informed embryo selection

Evaluates embryos for structural chromosomal balance

Helps guide treatment planning for couples with rearrangements

Provides greater clarity following recurrent pregnancy loss

Supports personalized fertility care

Integrates advanced genetic evaluation into IVF treatment

Enables evidence-based clinical decision-making

Comparison

How is PGT-SR Different from PGT-A and PGT-M?

Although all three procedures involve genetic testing during IVF, they are performed for different reasons. Your fertility specialist will recommend the most appropriate test based on your reproductive history, genetic evaluation, and treatment goals.

Test	Purpose
PGT-A	Evaluates whether an embryo has the correct number of chromosomes.
PGT-M	Detects a known inherited single-gene (monogenic) disorder.
PGT-SR	Assesses embryos when a parent carries a structural chromosomal rearrangement.

Evaluation

Is PGT-SR Right for Everyone?

No.

PGT-SR is recommended only when a structural chromosomal rearrangement has been identified or when genetic evaluation indicates that additional embryo testing may be beneficial.

At Agam, every recommendation is based on medical necessity rather than routine practice. We believe advanced genetic testing should be personalized, transparent, and guided by evidence.

Agam Advantage

Why Choose Agam for PGT-SR?

Complex fertility conditions require more than advanced technology; they require experience, careful evaluation, and compassionate guidance. At Agam Fertility and Women Centre, PGT-SR is integrated into a personalized fertility plan developed around your individual reproductive and genetic profile. From genetic counselling to embryo selection, every step is designed to help you make informed decisions with confidence.

Personalized fertility and genetic assessment

Individualized treatment planning

Advanced embryology and genetics support

Experienced fertility specialist-led care

Ethical, evidence-based patient care

Support

Frequently Asked Questions

PGT-SR is used to evaluate embryos when one or both partners have a structural chromosomal rearrangement, helping fertility specialists identify embryos with balanced chromosome structures before transfer.

PGT-A checks whether an embryo has the correct number of chromosomes, while PGT-SR focuses on structural chromosome rearrangements such as balanced translocations and inversions.

No. PGT-SR is recommended only for patients with confirmed structural chromosomal rearrangements or when advised following genetic evaluation.

No. PGT-SR provides important genetic information to support embryo selection, but pregnancy outcomes also depend on factors such as embryo quality, uterine health, age, and overall reproductive health.

No. It is a specialized procedure recommended only when clinically appropriate based on genetic findings.

Yes. Genetic counselling helps explain the nature of structural chromosomal rearrangements, discusses available testing options, and supports informed treatment decisions.

Personalized Care for Every Genetic Journey

When fertility challenges involve complex genetic factors, having the right guidance can make all the difference. PGT-SR provides valuable insights that help support informed embryo selection and individualized treatment planning. At Agam Fertility and Women Centre, we combine advanced reproductive technology with compassionate, patient-centred care, helping you move forward with confidence, clarity, and hope.

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PGT-SR Testing