PGT-M Inherited Genetic Screening in Chennai | Monogenic Disorders

Planning a family can feel overwhelming when there is a known inherited genetic condition. PGT-M (Preimplantation Genetic Testing for Monogenic Disorders) helps identify embryos that do not carry a specific inherited genetic disorder before embryo transfer during an IVF cycle.

At Agam Fertility and Women Centre, we combine advanced genetic testing with personalized fertility care to support informed family planning. Our specialists recommend PGT-M based on your medical history, genetic risk, and individual reproductive goals.

What is PGT-M?

PGT-M is a specialized genetic test performed during IVF to detect specific inherited single-gene (monogenic) disorders in embryos before they are transferred to the uterus. A few cells are carefully collected from each embryo and analyzed in a specialized genetics laboratory, helping fertility specialists identify unaffected embryos and support informed embryo selection for a healthier pregnancy.

Genetic Disorders

Understanding Monogenic Disorders

Monogenic disorders are conditions caused by a change (mutation) in a single gene. These inherited conditions can be passed from parents to their children, even when the parents themselves may not show symptoms. The specific condition tested depends entirely on the genetic mutation identified in the family.

Thalassemia

Sickle Cell Disease

Cystic Fibrosis

Spinal Muscular Atrophy (SMA)

Huntington's Disease

Inherited Metabolic Disorders

Purpose

Why is PGT-M Performed?

For couples with a known hereditary condition, PGT-M provides valuable genetic information before pregnancy begins.

Identify embryos that do not carry the targeted inherited disorder

Support informed embryo selection

Reduce the likelihood of passing genetic conditions to future children

Personalize fertility treatment based on genetic risk

Support family planning with greater confidence

Rather than treating a genetic disorder, PGT-M helps guide embryo selection during IVF based on known genetic information.

Candidacy

Who May Benefit from PGT-M?

PGT-M may be recommended for individuals or couples with a known risk of passing on an inherited genetic disorder. A comprehensive fertility and genetic evaluation helps determine whether PGT-M is appropriate for your individual circumstances.

Are known carriers of the same genetic condition

Have previously had a child affected by a hereditary disorder

Have a family history of a specific genetic disease

Have undergone genetic counselling and testing

Wish to reduce risk of passing a known inherited condition

Are planning IVF because of a hereditary genetic disorder

Recommendations

When is PGT-M Recommended?

PGT-M is usually considered when there is an identified genetic condition within the family. Every recommendation is made after careful medical evaluation and genetic consultation.

Both Partners Carry Mutation

When there is an increased likelihood of passing an inherited disorder to a child.

Family History of Disease

When close family members have been diagnosed with a hereditary condition.

Previous Affected Pregnancy

To support future family planning after an affected pregnancy.

Following Genetic Counselling

When genetic testing confirms an inherited condition that may affect future pregnancies.

Process

How Does PGT-M Work?

PGT-M is performed as part of an IVF cycle and involves several carefully coordinated stages.

1

Genetic Consultation

Your fertility specialist reviews your reproductive history, family history, and previous genetic reports. Genetic counselling helps determine suitability.

2

IVF Treatment

Eggs are collected and fertilized in the embryology laboratory to create embryos.

3

Embryo Biopsy

Once the embryos reach the blastocyst stage, a small number of cells are carefully removed from the outer layer of each embryo.

4

Genetic Analysis

The biopsied cells are analyzed to determine whether each embryo carries the specific inherited genetic mutation identified in the family.

5

Embryo Cryopreservation

The embryos are safely frozen while genetic analysis is completed.

6

Embryo Transfer

Based on the test results and your overall fertility assessment, your fertility specialist recommends an embryo for transfer.

Every stage is performed using advanced laboratory protocols to support accurate testing and individualized treatment planning.

Advantages

Benefits of PGT-M

For suitable patients, PGT-M offers important advantages during fertility treatment. The value of PGT-M depends on each couple's medical history and genetic background.

Supports informed embryo selection

Identifies embryos affected by inherited genetic disorders

Helps guide family planning decisions

Personalized fertility treatment

Integrates genetic evaluation with IVF

Provides greater clarity during treatment planning

Supports evidence-based reproductive care

Evaluation

Is PGT-M Right for Everyone?

No.

PGT-M is designed specifically for couples who have a known inherited genetic condition or an identified genetic risk. It is not routinely recommended for every IVF patient.

At Agam, every recommendation is made only after detailed fertility assessment, genetic counselling, and discussion with our specialists. Our goal is to ensure that every investigation has a clear clinical purpose and supports informed decision-making.

Agam Difference

Why Choose Agam for PGT-M?

When fertility care involves genetic conditions, expertise, precision, and compassionate guidance become equally important. At Agam Fertility and Women Centre, we take a personalized approach to every fertility journey, combining advanced reproductive technology with thoughtful clinical care. From fertility evaluation to genetic counselling and embryo selection, every step is planned around your unique medical needs and family-building goals.

Individualized fertility and genetic assessment & experienced specialists

Personalized treatment planning & collaborative genetics care

Evidence-based reproductive care & advanced embryology support

Ethical, transparent medical guidance & compassionate patient-centred care

Support

Frequently Asked Questions

PGT-M is used to identify embryos that may carry a specific inherited genetic disorder before embryo transfer during an IVF cycle.

No. PGT-M looks for a known single-gene (monogenic) disorder, while PGT-A evaluates whether an embryo has the correct number of chromosomes. Each test has a different purpose and may be recommended based on individual medical needs.

No. PGT-M is recommended only for patients with a known inherited genetic condition or a confirmed genetic risk identified through evaluation or genetic counselling.

No. PGT-M helps identify embryos based on a specific inherited genetic condition being tested. It does not eliminate all medical or genetic risks, and pregnancy outcomes depend on several factors.

Embryo biopsy is performed by experienced embryologists using specialized laboratory techniques. Your fertility specialist will discuss the benefits, considerations, and suitability of PGT-M based on your individual treatment plan.

Yes. Genetic counselling is an important part of the process. It helps explain inheritance patterns, discusses available testing options, and ensures that treatment decisions are based on a clear understanding of your family's genetic history.

Building Families with Confidence and Care

When hereditary genetic conditions become part of your fertility journey, having the right guidance can make all the difference. PGT-M offers valuable insights that support informed embryo selection and thoughtful family planning. At Agam Fertility and Women Centre, we are committed to providing advanced fertility care that combines scientific precision with compassionate support helping you move forward with confidence, clarity, and hope.

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